
                                SEQUENCE LISTING

<110> PROLYNX LLC
      SCHNEIDER, Eric L.
      HEARN, Brian
      HENISE, Jeffrey C.
      ASHLEY, Gary W.
      SANTI, Daniel V.
      

<120> EXTENDED RELEASE CONJUGATES OF EXENATIDE ANALOGS

<130> 670572001640

<140> PCT/US2017/022791   
<141> 2017-03-16  

<150> US 62/416,058       
<151> 2016-11-01  

<150> US 62/309,330       
<151> 2016-03-16  

<160> 12

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 39
<223> modified to have NH2

<400> 1
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser
        35                  


<210> 2
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 39
<223> modified to have NH2

<400> 2
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser
        35                  


<210> 3
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 39
<223> modified to have NH2

<400> 3
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser
        35                  


<210> 4
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 39
<223> modified to have NH2

<400> 4
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Lys Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser
        35                  


<210> 5
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 39
<223> modified to have NH2

<400> 5
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asp Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser
        35                  


<210> 6
<211> 43
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 43
<223> modified to have NH2

<400> 6
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gly Gly Pro Ser Ser
            20                  25                  30          
Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys
        35                  40              


<210> 7
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 44
<223> modified to have NH2

<400> 7
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys
        35                  40                  


<210> 8
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 44
<223> modified to have NH2

<400> 8
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys
        35                  40                  


<210> 9
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 44
<223> modified to have NH2

<400> 9
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Lys Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys
        35                  40                  


<210> 10
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 40
<223> modified to have NH2

<400> 10
Glu Leu Val Asp Asn Ala Val Gly Gly Asp Leu Ser Lys Gln Met Glu
 1               5                  10                  15      
Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro
            20                  25                  30          
Ser Ser Gly Ala Pro Pro Pro Ser
        35                  40  


<210> 11
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> AMIDATION      
<222> 30
<223> modified to have NH2

<220>
<221> VARIANT
<222> 2, 29 
<223> Xaa = Aib

<400> 11
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa Arg
            20                  25                  30  


<210> 12
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 12
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly
            20                  25                  30      

